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| Nomenclature |
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Symbol:
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Tg(SOD1*G93A)2Gur
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Name:
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transgene insertion 2, Mark E Gurney
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MGI ID: |
MGI:2183718 |
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Synonyms: |
G1, G1L, hMg-SOD1(G93A), Tg(SOD1)2Gur, Tg(SOD1-G93A)2Gur |
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Transgene:
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Tg(SOD1*G93A)2Gur
Location:
unknown
Genetic Position: Chr12,
Syntenic
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct consists of a human SOD1 gene carrying a glycine to alanine substitution at position 93 (G93A). The G93A mutation does not alter the activity of the protein. Northern blot and Western blot confirmed the expression of the human transgene in transgenic animals. (J:32665, J:43332, J:43347)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
This is the original high copy number line, G1, reported in J:32556. Subsequently, the Tg(SOD1*G93A)1Gur line, which has a 40% greater copy number was derived from the original founder G1 and reported in J:76718.
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| References |
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Original: |
J:32665
Gurney ME et al.,
"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]"
Science 1994 Jun 17;264(5166):1772-5
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All: |
48 reference(s)
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Analysis Tools
