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| Nomenclature |
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Symbol:
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Itgb4tm1Efu
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Name:
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integrin beta 4;
targeted mutation 1, Elaine Fuchs
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MGI ID: |
MGI:2183630 |
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Synonyms: |
beta4- |
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Gene:
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Itgb4
Location:
Chr11:115974709-116008412 bp, + strand
Genetic Position: Chr11,
80.91 cM
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Separation at the mesenchymal-epithelial junctions in skin of Itgb4tm1Efu/Itgb4tm1Efu mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77644
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The insertion of a neomycin selection cassette deleted sequence extending from 115 base pairs downstream of the start codon through intron 3. The absence of normal transcript in homozygous mutant mice was determined via RT-PCR analysis. While truncated transcript was detected, immunoblot analysis showed an absence of protein. (J:77644)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Itgb4 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:77644
Dowling J et al.,
"Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival."
J Cell Biol 1996 Jul;134(2):559-72
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All: |
2 reference(s)
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Analysis Tools
