|
|
| Nomenclature |
|
Symbol:
|
Prkar1atm1Gsm
|
|
Name:
|
protein kinase, cAMP dependent regulatory, type I, alpha;
targeted mutation 1, G Stanley McKnight
|
|
MGI ID: |
MGI:2183602 |
|
Gene:
|
Prkar1a
Location:
Chr11:109649405-109669656 bp, + strand
Genetic Position: Chr11,
72.33 cM
|
|
Tumors in Prkar1atm1Gsm/Prkar1a+ mice
Show the 4 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:78010
|
|
Parent Cell Line:
| REK2 (ES Cell) |
|
Strain of Origin:
|
129X1/SvJ
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Exon 3 was disrupted by the insertion of a neomycin selection cassette. The absence of endcoded protein in homozygous mutant mice was confirmed via Western blot analysis. (J:78010)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:78010
Amieux PS et al.,
"Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo."
J Biol Chem 2002 Jul 26;277(30):27294-304
|
|
All: |
5 reference(s)
|
|
Analysis Tools
