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| Nomenclature |
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Symbol:
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Mc3rtm1Lvp
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Name:
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melanocortin 3 receptor;
targeted mutation 1, Lex H T Van der Ploeg
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MGI ID: |
MGI:2183582 |
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Synonyms: |
MC3-, Mc3r- |
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Gene:
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Mc3r
Location:
Chr2:172248492-172251114 bp, + strand
Genetic Position: Chr2,
94.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64365
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire coding region was replaced with a neomycin selection cassette. Transcript was identified to be absent in the brains of homozygous mutant mice via in situ hybridization. (J:64365)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mc3r Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:64365
Chen AS et al.,
"Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass"
Nat Genet 2000 Sep;26(1):97-102
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All: |
6 reference(s)
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Analysis Tools
