|
|
| Nomenclature |
|
Symbol:
|
Mc3rtm1Cone
|
|
Name:
|
melanocortin 3 receptor;
targeted mutation 1, Roger D Cone
|
|
MGI ID: |
MGI:2183579 |
|
Synonyms: |
mc3r- |
|
Gene:
|
Mc3r
Location:
Chr2:172248492-172251114 bp, + strand
Genetic Position: Chr2,
94.8 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:78132
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: 0.7kb of sequence was replaced with a neomycin selection cassette at the initiation codon. Homozygous mutant mice were shown to lack transcript via RT-PCR analysis of total hypthalamic RNA. (J:78132)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:78132
Butler AA et al.,
"A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse."
Endocrinology 2000 Sep;141(9):3518-21
|
|
All: |
12 reference(s)
|
|
Analysis Tools
