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| Nomenclature |
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Symbol:
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Pth1rtm3Hmk
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Name:
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parathyroid hormone 1 receptor;
targeted mutation 3, Henry M Kronenberg
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MGI ID: |
MGI:2183514 |
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Synonyms: |
Pthrd/d |
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Gene:
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Pth1r
Location:
Chr9:110722088-110743686 bp, - strand
Genetic Position: Chr9,
60.56 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77683
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: This hypomorphic allele was identified in conjunction with Pthrtm2Hmk. Southern blot analyses showed three copies of the targeting vector, containing a floxed exon 1, at the endogenous locus. Levels of transcript were determined to be reduced in homozygous mutant mice via in situ hybridization of the growth plate and Northern blot analysis of total renal RNA. (J:77683)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pth1r Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:77683
Kobayashi T et al.,
"PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps."
Development 2002 Jun;129(12):2977-86
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All: |
2 reference(s)
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Analysis Tools
