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| Nomenclature |
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Symbol:
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Tgfbr2tm1Karl
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Name:
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transforming growth factor, beta receptor II;
targeted mutation 1, Stefan Karlsson
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MGI ID: |
MGI:2183502 |
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Synonyms: |
floxed-TbetaRII, T-Beta-RII flox, Tgfbr2fl, Tgfbr2fl |
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Gene:
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Tgfbr2
Location:
Chr9:116087698-116175363 bp, - strand
Genetic Position: Chr9,
68.39 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77844
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exon 4 was left flanked by single loxP sites in introns 3 and 5 after a floxed neo cassette was excised via cre-mediated recombination in ES cells. (J:77844)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:77844
Leveen P et al.,
"Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable."
Blood 2002 Jul 15;100(2):560-8
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All: |
25 reference(s)
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Analysis Tools
