|
|
| Nomenclature |
|
Symbol:
|
Mdm4tm1Glo
|
|
Name:
|
transformed mouse 3T3 cell double minute 4;
targeted mutation 1, Guillermina Lozano
|
|
MGI ID: |
MGI:2183485 |
|
Synonyms: |
Mdm4- |
|
Gene:
|
Mdm4
Location:
Chr1:132989845-133025348 bp, - strand
Genetic Position: Chr1,
57.75 cM, cytoband G-G
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:71532
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
Not Specified
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Exons 3 through 5 were replaced with a neomycin selection cassette. The deleted region encoded the majority of the Trp53-binding domain (amino acids 27-96). Aberrant splicing around the neo transgene would result in a frameshift mutation. Protein was undetected in homozygous mutant mice by Western blot analysis. (J:71532)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:71532
Parant J et al.,
"Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53."
Nat Genet 2001 Sep;29(1):92-5
|
|
All: |
11 reference(s)
|
|
Analysis Tools
