|
|
| Nomenclature |
|
Symbol:
|
Alpltm1Jlm
|
|
Name:
|
alkaline phosphatase, liver/bone/kidney;
targeted mutation 1, Jose Luis Millan
|
|
MGI ID: |
MGI:2183411 |
|
Synonyms: |
Akp2-, Akp2 KO, TNAP- |
|
Gene:
|
Alpl
Location:
Chr4:137741733-137796384 bp, - strand
Genetic Position: Chr4,
70.02 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:39015
|
|
Parent Cell Line:
| D3 (ES Cell) |
|
Strain of Origin:
|
129S2/SvPas
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 6 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot and RT-PCR analysis. (J:39015)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:39015
Narisawa S et al.,
"Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia."
Dev Dyn 1997 Mar;208(3):432-46
|
|
All: |
12 reference(s)
|
|
Analysis Tools
