|
|
| Nomenclature |
|
Symbol:
|
Runx3tm1Yg
|
|
Name:
|
runt related transcription factor 3;
targeted mutation 1, Yoram Groner
|
|
MGI ID: |
MGI:2183399 |
|
Synonyms: |
Runx3- |
|
Gene:
|
Runx3
Location:
Chr4:135120652-135177990 bp, + strand
Genetic Position: Chr4,
67.19 cM
|
|
Pathological findings in large intestines of Runx3tm1Yg/Runx3tm1Yg and +/+ wild-type.
Show the 3 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:77764
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Reporter) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Exon 2, encoding the runt domain, was disrupted by the insertion of a cassette containing IRES-lacZ and neo. RT-PCR analysis of dorsal root ganglia RNA extracts showed an absence of transcript in homozygous mutant mice. Protein was undetected by Western blot analysis of thymus tissue and immunostaining of dorsal root ganglia. Expression of beta-galactosidase was visualized in mutant embryos via X-gal staining. (J:77764)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Runx3 Mutation:
|
3 strains or lines available |
|
|
Notes |
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:93240).
|
| References |
|
Original: |
J:77764
Levanon D et al.,
"The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons."
EMBO J 2002 Jul 1;21(13):3454-63
|
|
All: |
14 reference(s)
|
|
Analysis Tools
