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| Nomenclature |
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Symbol:
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Ptentm1Mro
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Name:
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phosphatase and tensin homolog;
targeted mutation 1, Silvia Marino
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MGI ID: |
MGI:2183284 |
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Synonyms: |
Ptenfl, Ptenflox, Ptenfx, PtenLoxP |
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Gene:
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Pten
Location:
Chr19:32757497-32826160 bp, + strand
Genetic Position: Chr19,
28.14 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77123
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector which contained a floxed neomycin selection cassette in intron 4 and a loxP site in intron 5 was electroporated into ES cells that were subsequently transiently transfected with a cre recombinase expression plasmid. The expression of cre resulted in the excision of the neo transgene, leaving exon 5 flanked by loxP sites. Mice carrying this allele were used to generate Ptentm1.1. (J:77123)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:77123
Marino S et al.,
"PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum."
Development 2002 Jul;129(14):3513-22
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All: |
15 reference(s)
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Analysis Tools
