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| Nomenclature |
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Symbol:
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Upk3atm1Tsun
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Name:
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uroplakin 3A;
targeted mutation 1, Tung-Tien Sun
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MGI ID: |
MGI:2183244 |
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Synonyms: |
UPIII(-) |
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Gene:
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Upk3a
Location:
Chr15:85017141-85022560 bp, + strand
Genetic Position: Chr15,
40.25 cM, cytoband E3
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Urothelium lacks the umbrella cells and is leaky in Upk3atm1Tsun/Upk3atm1Tsun mice
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77653
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Parent Cell Line:
| W4 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced the first exon and introduced a frameshift mutation that affected the remaining exons. Neither transcript nor protein was detected in homozygous mutant mice via Northern blot and Western blot analyses. (J:77653)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Upk3a Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:77653
Hu P et al.,
"Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux."
J Cell Biol 2000 Nov 27;151(5):961-72
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All: |
3 reference(s)
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Analysis Tools
