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| Nomenclature |
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Symbol:
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Ror2tm1Ymi
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Name:
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receptor tyrosine kinase-like orphan receptor 2;
targeted mutation 1, Yasuhiro Minami
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MGI ID: |
MGI:2183225 |
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Synonyms: |
mRor2-, Ror2- |
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Gene:
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Ror2
Location:
Chr13:53109312-53286124 bp, - strand
Genetic Position: Chr13,
27.68 cM, cytoband B3
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Ror2Y324C/Ror2Y324C and Ror2tm1Ymi/Ror2tm1Ymi mice exhibit short tails at E10.75
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:60125
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exons encoding an Ig-like domain with a neomycin resistance gene via homologous recombination. Western blot analysis confirmed the absence of protein expression in neural progenitor cells from homozygous mice. (J:60125, J:182150)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ror2 Mutation:
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73 strains or lines available |
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| References |
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Original: |
J:60125
Takeuchi S et al.,
"Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation."
Genes Cells 2000 Jan;5(1):71-8
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All: |
21 reference(s)
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Analysis Tools
