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| Nomenclature |
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Symbol:
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Nfatc4tm1Grc
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Name:
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nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4;
targeted mutation 1, Gerald R Crabtree
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MGI ID: |
MGI:2183093 |
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Synonyms: |
c4-, NFATc4- |
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Gene:
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Nfatc4
Location:
Chr14:55824795-55833943 bp, + strand
Genetic Position: Chr14,
28.19 cM, cytoband C1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70266
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1-2 and part of exon 3 were replaced with neomycin resistance gene via homologous recombination. This region of the gene encodes amino acids 1-413 and contains the translation start site, a regulatory domain that controls calmodulin-dependent cytoplasmic-to-nuclear translocation, and part of the DNA-binding domain. Western blot and RNase protection assay of homozygous mutant embryos verified the absence of gene expression. (J:70266)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nfatc4 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:70266
Graef IA et al.,
"Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature."
Cell 2001 Jun 29;105(7):863-75
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All: |
6 reference(s)
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Analysis Tools
