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| Nomenclature |
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Symbol:
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Efna2tm1Jgf
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Name:
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ephrin A2;
targeted mutation 1, John G Flanagan
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MGI ID: |
MGI:2182943 |
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Synonyms: |
A2-, ephrin-A2- |
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Gene:
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Efna2
Location:
Chr10:80179482-80190010 bp, + strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61499
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette, containing stop codons in all three reading frames, was inserted after the sequence encoding amino acid 66. The insertion was upstream of a conserved cysteine residue motif. RT-PCR analysis of midbrain RNA showed an absence of transcript in homozygous mutant embryos. (J:61499)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:61499
Feldheim DA et al.,
"Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping [see comments]"
Neuron 2000 Mar;25(3):563-74
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All: |
20 reference(s)
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Analysis Tools
