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| Nomenclature |
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Symbol:
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Faahtm1Crv
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Name:
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fatty acid amide hydrolase;
targeted mutation 1, Benjamin F Cravatt
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MGI ID: |
MGI:2182901 |
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Synonyms: |
FAAH- |
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Gene:
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Faah
Location:
Chr4:115967145-116017926 bp, - strand
Genetic Position: Chr4,
53.08 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70666
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 and approximately 2kb of upstream sequence were replaced by a PGK-neo selection cassette. Western blot analysis of brain and liver protein extracts and immunofluorescence analysis of cerebral sections showed an absence of encoded protein in homozygous mutant mice. Assays using labeled substrate showed significant reductions (50-100 fold) of hydrolytic activity in homozygous mutant mice. (J:70666)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Faah Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:70666
Cravatt BF et al.,
"Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase."
Proc Natl Acad Sci U S A 2001 Jul 31;98(16):9371-6
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All: |
41 reference(s)
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Analysis Tools
