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| Nomenclature |
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Symbol:
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Per2tm1Drw
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Name:
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period circadian clock 2;
targeted mutation 1, David R Weaver
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MGI ID: |
MGI:2182832 |
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Synonyms: |
mPer2ldc, Per2-, Per2m |
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Gene:
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Per2
Location:
Chr1:91415982-91459328 bp, - strand
Genetic Position: Chr1,
46.13 cM, cytoband C5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69626
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 5 and a portion of exon 6 were replaced with a neomycin selection cassette. Several transcript forms produced from the targeted allele were identified in homozygous mutant mice via RT-PCR and RACE analyses of brain RNA. The different transcripts involved aberrant splicing of exon 4 to a pseudoexon in intron 4, to a cryptic splice site within neo, and to exon 7. In spite of the transcripts having in-frame regions, normal protein was undetected in by immunohistochemical staining of superchiasmatic nuclei over a 24 hour period. (J:69626)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:69626
Bae K et al.,
"Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock."
Neuron 2001 May;30(2):525-36
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All: |
25 reference(s)
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Analysis Tools
