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| Nomenclature |
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Symbol:
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Epb4.2tm1Llp
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Name:
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erythrocyte protein band 4.2;
targeted mutation 1, Luanne L Peters
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MGI ID: |
MGI:2182816 |
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Synonyms: |
4.2- |
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Gene:
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Epb4.2
Location:
Chr2:121017891-121037072 bp, - strand
Genetic Position: Chr2,
60.37 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67412
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: Sequence from exons 4 through 8 was deleted by the insertion of a neomycin selection cassette. Northern blot analysis of total reticulocyte RNA and RNase protection assays of nonerythroid tissue samples did not detect message encoded by the targeted allele. Protein was determined to be absent in erythroid cells from homozygous mutant mice via Western blot analysis and Coomassie blue staining. (J:67412)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:67412
Peters LL et al.,
"Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice."
J Clin Invest 1999 Jun;103(11):1527-37
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All: |
4 reference(s)
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Analysis Tools
