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| Nomenclature |
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Symbol:
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Nfatc2tm1Glm
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Name:
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nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2;
targeted mutation 1, Laurie H Glimcher
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MGI ID: |
MGI:2182740 |
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Synonyms: |
c2-, NFATc2-, NF-ATp-mut |
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Gene:
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Nfatc2
Location:
Chr2:168476410-168601657 bp, - strand
Genetic Position: Chr2,
88.91 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:32728
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced sequences encoding 47 amino acids of the Rel homology domain. An absence of normal protein in homozygous mutant mice was determined through Western blot analysis. Low levels of reactive polypeptides were present in the cytoplasm, however, no reactivity was observed in the nucleus. RT-PCR and sequence analysis revealed aberrantly spliced in-frame transcripts from which the targeted exon had been excised. An electrophoretic mobility shift assay confirmed that DNA was not binding to the mutant protein. (J:32728)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nfatc2 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:32728
Hodge MR et al.,
"Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice."
Immunity 1996 Apr;4(4):397-405
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All: |
32 reference(s)
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Analysis Tools
