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| Nomenclature |
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Symbol:
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Gadd45atm1Ajf
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Name:
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growth arrest and DNA-damage-inducible 45 alpha;
targeted mutation 1, Albert J Fornace
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MGI ID: |
MGI:2182720 |
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Synonyms: |
Gadd45a- |
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Gene:
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Gadd45a
Location:
Chr6:67035096-67037457 bp, - strand
Genetic Position: Chr6,
30.72 cM
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Exencephaly in Brca1tm2.1Cxd/Brca1tm2.1Cxd Gadd45atm1Ajf/Gadd45atm1Ajf embryos
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57882
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 2.5 kb of the promoter and exons 1-3 were replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutants was verified by RNase protection assay using an exon 3 probe and mouse embryonic fibroblasts derived from E13.5 homozygous mutant embryos. (J:57882)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gadd45a Mutation:
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2 strains or lines available |
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Notes |
ES cell line = ESVJ-1183 (129X1/SvJ) or HM-1 (129P2/OlaHsd).
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| References |
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Original: |
J:57882
Hollander MC et al.,
"Genomic instability in Gadd45a-deficient mice."
Nat Genet 1999 Oct;23(2):176-84
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All: |
20 reference(s)
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Analysis Tools
