|
|
| Nomenclature |
|
Symbol:
|
Il21rtm1Day
|
|
Name:
|
interleukin 21 receptor;
targeted mutation 1, Debra A Young
|
|
MGI ID: |
MGI:2182707 |
|
Synonyms: |
IL-21R- |
|
Gene:
|
Il21r
Location:
Chr7:125603429-125633570 bp, + strand
Genetic Position: Chr7,
68.98 cM, cytoband F4
|
|
Impaired allergic skin inflammation and systemic response to epicutaneous sensitization in Il21rtm1Day/Il21rtm1Day mice
Show the 1 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:76043
|
|
Parent Cell Line:
| Other (see notes) (ES Cell) |
|
Strain of Origin:
|
C57BL/6
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Exon 1 was replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression was verified by PCR of total RNA from homozygous mutant animals. (J:76043)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Il21r Mutation:
|
6 strains or lines available |
|
|
Notes |
ES cell line = J12.
|
| References |
|
Original: |
J:76043
Kasaian MT et al.,
"IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation. A Mediator of the Transition from Innate to Adaptive Immunity."
Immunity 2002 Apr;16(4):559-69
|
|
All: |
17 reference(s)
|
|
Analysis Tools
