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| Nomenclature |
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Symbol:
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Zfpm2tm1Jml
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Name:
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zinc finger protein, multitype 2;
targeted mutation 1, Jeffrey M Leiden
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MGI ID: |
MGI:2182616 |
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Synonyms: |
Fog-2-, Zfpm2- |
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Gene:
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Zfpm2
Location:
Chr15:40655042-41104592 bp, + strand
Genetic Position: Chr15,
15.74 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63121
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The majority of exons 6 and 7 was replaced with a neomycin selection cassette. The replaced region encoded all zinc fingers of the encoded protein. Western blot analysis of homozygous mutant embryonic tissue showed an absence of protein. (J:63121)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Zfpm2 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:63121
Svensson EC et al.,
"A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2."
Nat Genet 2000 Jul;25(3):353-6
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All: |
3 reference(s)
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Analysis Tools
