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| Nomenclature |
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Symbol:
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Krt5tm1Tmm
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Name:
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keratin 5;
targeted mutation 1, Thomas M Magin
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MGI ID: |
MGI:2182612 |
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Synonyms: |
K5- |
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Gene:
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Krt5
Location:
Chr15:101707070-101712891 bp, - strand
Genetic Position: Chr15,
56.98 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76311
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The promoter and first 2 exons were replaced with an Hprt cassette via homologous recombination. Northern blot of homozygous mutant animals showed complete absence of gene expression. Western blot analysis of skin protein extracts from homozygous mutants showed lack of protein expression. (J:76311)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:76311
Peters B et al.,
"Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex."
Mol Biol Cell 2001 Jun;12(6):1775-89
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All: |
4 reference(s)
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Analysis Tools
