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| Nomenclature |
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Symbol:
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Brca1tm2.1Cxd
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Name:
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breast cancer 1;
targeted mutation 2.1, Chu-Xia Deng
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MGI ID: |
MGI:2182470 |
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Synonyms: |
Brca1delta11, Brcadelta11 |
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Gene:
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Brca1
Location:
Chr11:101488764-101551955 bp, - strand
Genetic Position: Chr11,
65.18 cM, cytoband D
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Exencephaly and growth retardation in Brca1tm2.1Cxd/Brca1tm2.1Cxd Gadd45atm1Ajf/Gadd45atm1Ajf embryos
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70271
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele, lacking exon 11, was generated by crossing mice heterozygous for Brca1tm2Cxd with transgenic mice expressing the cre recombinase gene via the EIIa promoter which is active in germ cells. Northern blot analysis of homozygous mutant embryos indicated an absence of full length transcript. Transcript lacking exon 11 was detected in both wild-type and mutant embryos, though the levels were increased in homozygous mutant embyros. (J:70271)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:70271
Xu X et al.,
"Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis."
Nat Genet 2001 Jul;28(3):266-71
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All: |
18 reference(s)
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Analysis Tools
