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| Nomenclature |
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Symbol:
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Dnmt3atm1Enl
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Name:
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DNA methyltransferase 3A;
targeted mutation 1, En Li
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MGI ID: |
MGI:2182408 |
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Gene:
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Dnmt3a
Location:
Chr12:3806007-3914443 bp, + strand
Genetic Position: Chr12,
1.99 cM, cytoband A2-A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58298
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 0.3kb region encoding the PC and ENV motifs was replaced with a cassette containing an IRES-lacZ gene and a neo gene. Northern blot analysis of total RNA showed an absence of transcript in homozygous mutant mice. X-gal staining of heterozygous embryos revealed expression of beta-galactosidase. (J:58298)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:58298
Okano M et al.,
"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development."
Cell 1999 Oct 29;99(3):247-57
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All: |
3 reference(s)
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Analysis Tools
