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| Nomenclature |
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Symbol:
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Gtf2ird1Tg(Alb1-Myc)166.8Sst
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Name:
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general transcription factor II I repeat domain-containing 1;
transgene insertion 166.8, Snorri S Thorgeirsson
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MGI ID: |
MGI:2182322 |
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Synonyms: |
Alb-c-myc line 166.8, Alb/c-myc line 166.8, c-myc line 166.8, Gtf2ird1-, Tg(Alb1-Myc)166.8Sst |
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Gene:
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Gtf2ird1
Location:
Chr5:134357669-134456716 bp, - strand
Genetic Position: Chr5,
74.55 cM
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA/J)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: A transgene construct consisting of mouse Myc under the control of the mouse albumin promoter replaced of approximately 40 kb of chromosome 5, encompassing sequence downstream of Cyln2 through the first exon of Gtf2ird1. Northern blot and RT-PCR analysis of heart, muscle, liver, and spleen tissue from homozygous mutant mice showed highly reduced levels of Gtf2ird1 transcript. (J:4527, J:68983)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gtf2ird1 Mutation:
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303 strains or lines available |
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Notes |
Integration was mapped to a region on chromosome 5 that is orthologous to a human region hemizygously deleted in Williams-Beuren syndrome patients.
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| References |
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Original: |
J:4527
Murakami H et al.,
"Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis."
Cancer Res 1993 Apr 15;53(8):1719-23
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All: |
23 reference(s)
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Analysis Tools
