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| Nomenclature |
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Symbol:
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Ctsktm1Psa
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Name:
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cathepsin K;
targeted mutation 1, Paul Saftig
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MGI ID: |
MGI:2182131 |
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Synonyms: |
Cathk-, CatK-, K- |
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Gene:
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Ctsk
Location:
Chr3:95499286-95509362 bp, + strand
Genetic Position: Chr3,
40.74 cM
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Radiographs and histological analysis of Ctsktm1Psa/Ctsktm1Psa mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50934
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 7. An absence of transcript generated from this allele was determined by Northern blot and RT-PCR analyses of total bone RNA. Western blot analysis of protein extracts from homozygous mutant bone showed a lack or encoded protein. (J:50934)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ctsk Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:50934
Saftig P et al.,
"Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice."
Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13453-8
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All: |
15 reference(s)
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Analysis Tools
