|
|
| Nomenclature |
|
Symbol:
|
Tg(SOD1*G37R)106Dpr
|
|
Name:
|
transgene insertion 106, Donald L Price
|
|
MGI ID: |
MGI:2182087 |
|
Synonyms: |
SOD1G37R, Tg(SOD1-G37R)106Dpr, Tg(SOD1-G37R)106Pcw, Tg(SOD1G37R)106Pcw |
|
Transgene:
|
Tg(SOD1*G37R)106Dpr
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
(C57BL/6J x C3H/HeJ)F2
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A 12 kb genomic DNA fragment containing a mutated form of human SOD1 with a glycine to arginine substitution at amino acid 37 (G37R) was used for the transgene. The G37R mutation is found in some cases of familial amyotrophic lateral sclerosis (FALS). (J:69178)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
| References |
|
Original: |
J:69178
Wong PC et al.,
"An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria."
Neuron 1995 Jun;14(6):1105-16
|
|
All: |
7 reference(s)
|
|
Analysis Tools
