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| Nomenclature |
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Symbol:
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Tg(NFH)120Jpj
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Name:
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transgene insertion 120, Jean-Pierre Julien
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MGI ID: |
MGI:2182067 |
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Transgene:
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Tg(NFH)120Jpj
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The complete human NFH gene including 9.6 kb of 5' sequences and 13.4 kb of 3' sequences was used for the transgene. Expression of the human gene in transgenic animals was confirmed by Western blot analysis. (J:69180)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Founder 120 is representative of 2 founders carrying 2 and 3 copies of the transgene. These animals express approximately 50% the amount of endogenous mRNA and exhibit neurological anomalies at 6 months of age.
The phenotype is more severe in homozygous mice verses hemizygous mice, implying a correlation between phenotype and expression levels of NEFH.
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| References |
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Original: |
J:69180
Cote F et al.,
"Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis."
Cell 1993 Apr 9;73(1):35-46
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All: |
1 reference(s)
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Analysis Tools
