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| Nomenclature |
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Symbol:
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Ptentm2Mak
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Name:
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phosphatase and tensin homolog;
targeted mutation 2, Tak W Mak
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MGI ID: |
MGI:2182005 |
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Synonyms: |
PTENCo, Ptenf, Ptenfl, Ptenflox, PtenL, PtenloxP |
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Gene:
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Pten
Location:
Chr19:32757497-32826160 bp, + strand
Genetic Position: Chr19,
28.14 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69471
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Parent Cell Line:
| E14K (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: One loxP site was inserted in intron 3 and a floxed hygromycin selection cassette was inserted in intron 5. The hygromycin selection cassette was removed in ES cells by transient Cre expression, leaving exons 4 and 5 flanked by loxP sites in the final allele. (J:69471)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Cortical Dysplasia (Ptentm2Mak/Ptentm2Mak Tg(Gfap-cre)1Sbk mice, J:149829)
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| References |
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Original: |
J:69471
Suzuki A et al.,
"T cell-specific loss of pten leads to defects in central and peripheral tolerance."
Immunity 2001 May;14(5):523-34
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All: |
102 reference(s)
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Analysis Tools
