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| Nomenclature |
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Symbol:
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Ins2tm1Jja
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Name:
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insulin II;
targeted mutation 1, Jacques Jami
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MGI ID: |
MGI:2181878 |
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Synonyms: |
Ins2-, proins-2-, proinsulin 2- |
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Gene:
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Ins2
Location:
Chr7:142678656-142699510 bp, - strand
Genetic Position: Chr7,
88.0 cM
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Severe insulitis in Ins2tm1Jja/Ins2tm1Jja mice and lack of insulitis in Ins1tm1Jja/Ins1tm1Jja mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40377
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The majority of the coding region was replaced by the insertion of a lacZ-neo fusion gene. The expression of lacZ was found to be under the control of the endogenous promoter via cytochemical assays. (J:40377)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:40377
Duvillie B et al.,
"Phenotypic alterations in insulin-deficient mutant mice."
Proc Natl Acad Sci U S A 1997 May 13;94(10):5137-40
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All: |
23 reference(s)
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Analysis Tools
