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| Nomenclature |
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Symbol:
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Rhotm1Phm
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Name:
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rhodopsin;
targeted mutation 1, Peter Humphries
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MGI ID: |
MGI:2181812 |
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Synonyms: |
R-, Rho- |
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Gene:
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Rho
Location:
Chr6:115931927-115938829 bp, + strand
Genetic Position: Chr6,
53.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:38098
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette under the control of a polymerase II promoter was inserted at codon 135 in exon 2. RT-PCR analysis of total RNA derived from ocular tissue showed an absence of transcript in homozygous mutant mice. A lack of encoded protein was determined in homozygous mutant mice via immunocytochemical staining of retinal sections. (J:38098)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rho Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:38098
Humphries MM et al.,
"Retinopathy induced in mice by targeted disruption of the rhodopsin gene [see comments]"
Nat Genet 1997 Feb;15(2):216-9
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All: |
44 reference(s)
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Analysis Tools
