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| Nomenclature |
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Symbol:
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Plectm2Gwi
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Name:
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plectin;
targeted mutation 2, Gerhard Wiche
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MGI ID: |
MGI:2181792 |
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Synonyms: |
exon 2-4-deficient |
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Gene:
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Plec
Location:
Chr15:76170975-76232574 bp, - strand
Genetic Position: Chr15,
35.48 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:59000
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 2 through 4 were replaced by a neomycin selection cassette. The 5' end of exon 2 serves as a splice-acceptor site utilized in all four identified alternative transcripts. Transcript was undetected by RT-PCR analysis of samples derived from homozygous mutant skin and muscle tissue. An absence of protein was determined by immunoblot analysis of skin and muscle tissue derived from homozygous mutant mice. (J:59000)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Plec Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:59000
Andra K et al.,
"Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture."
Genes Dev 1997 Dec 1;11(23):3143-56
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All: |
3 reference(s)
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Analysis Tools
