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| Nomenclature |
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Symbol:
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L1camtm1Mtei
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Name:
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L1 cell adhesion molecule;
targeted mutation 1, Ned Mantei
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MGI ID: |
MGI:2181735 |
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Synonyms: |
L1- |
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Gene:
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L1cam
Location:
ChrX:73853778-73896105 bp, - strand
Genetic Position: ChrX,
37.43 cM, cytoband A6-B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43838
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Parent Cell Line:
| GS1 (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 8 was disrupted by the insertion of a construct containing adjacent thymidine kinase and neomycin resistance genes. Low levels of a truncated transcript were detected via Northern blot analysis of total RNA isolated from homozygous mutant brain tissue (data not shown). Western blot analysis of protein extracts from homozygous mutant brain tissue showed an absence of the four isoforms detected in extracts from normal brain tissue, though low levels of a 190kD aberrant transcript were detected. (J:43838)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any L1cam Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:43838
Dahme M et al.,
"Disruption of the mouse L1 gene leads to malformations of the nervous system."
Nat Genet 1997 Nov;17(3):346-9
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All: |
13 reference(s)
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Analysis Tools
