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| Nomenclature |
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Symbol:
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Tg(RHO-P23H)DTpd
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Name:
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transgene insertion D, Thaddeus P Dryja
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MGI ID: |
MGI:2181671 |
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Synonyms: |
P23H-D |
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Transgene:
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Tg(RHO-P23H)DTpd
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The entire coding region of mutant human rhodopsin (P23H) implicated in dominantly inherited retinitis pigmentosa was used for the transgene. The transgene includes 4.2 kb of upstream sequence and 8.4 kb of downstream sequence. (J:76722)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Mutant lines D, E, and L harboring the mutant human rhodopsin gene were constructed. Lines D and E express 3x and 1x the amount of endogenous rhodopsin, respectively, resulting in severe retinitis pigmentosa. Line L expresses 1/6x the amount of endogenous rhodopsin and exhibits a mild disease phenotype.
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| References |
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Original: |
J:76722
Olsson JE et al.,
"Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa."
Neuron 1992 Nov;9(5):815-30
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All: |
1 reference(s)
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Analysis Tools
