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| Nomenclature |
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Symbol:
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Ece2tm1Ywa
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Name:
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endothelin converting enzyme 2;
targeted mutation 1, Masashi Yanagisawa
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MGI ID: |
MGI:2181668 |
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Synonyms: |
ECE-2- |
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Gene:
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Ece2
Location:
Chr16:20611593-20646485 bp, + strand
Genetic Position: Chr16,
12.48 cM, cytoband B1
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Cardiac defects in Ece1tm1Reh/Ece1tm1Reh and Ece1tm1Reh/Ece1tm1Reh Ece2tm1Ywa/Ece2tm1Ywa embryos
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:62261
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 14 and 15, the latter of which encodes the essential conserved zinc-binding motif, were replaced with a neomycin selection cassette. RT-PCR analysis of total RNA extracted from homozygous mutant brain tissue showed an absence of expression. (J:62261)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ece2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:62261
Yanagisawa H et al.,
"Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development."
J Clin Invest 2000 May;105(10):1373-82
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All: |
6 reference(s)
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Analysis Tools
