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| Nomenclature |
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Symbol:
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Hprttm1(cre)Mnn
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Name:
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hypoxanthine guanine phosphoribosyl transferase;
targeted mutation 1, Jeffrey R Mann
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MGI ID: |
MGI:2181632 |
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Synonyms: |
Hprt1tm1(cre)Mnn, hprt-cre, Hprtcre, Hprttm1(CAG.cre)MdCoh |
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Gene:
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Hprt
Location:
ChrX:52988137-53021659 bp, + strand
Genetic Position: ChrX,
29.31 cM, cytoband A6
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Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75826
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: An expression cassette in which a CMV enhancer and chicken beta-globin promoter driving Cre recombinase expression was inserted in reverse transcriptional orientation into exon 3 of the gene. A PGK-neomycin selection cassette was also inserted following the cre gene. Expression of Cre recombinase occurred at high levels in the female germline and fertilized eggs, and all offspring of heterozyous females display excision of reporter sequences. (J:75826)
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Recombinase activity
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Activity in:
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alimentary system,
cardiovascular system,
embryo-other,
endocrine system,
hemolymphoid system,
integumental system,
liver & biliary system,
muscle,
nervous system,
postnatal-other,
renal & urinary system,
reproductive system,
respiratory system
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Driver:
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CAG
Summary of all recombinase alleles
driven by CAG.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:75826
Tang SH et al.,
"A cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ."
Genesis 2002 Mar;32(3):199-202
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All: |
51 reference(s)
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Analysis Tools
