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| Nomenclature |
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Symbol:
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Sox2tm2Skn
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Name:
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SRY-box containing gene 2;
targeted mutation 2, Silvia K Nicolis
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MGI ID: |
MGI:2181440 |
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Synonyms: |
allele 2, Sox2Beta-geo |
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Gene:
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Sox2
Location:
Chr3:34650405-34652461 bp, + strand
Genetic Position: Chr3,
16.93 cM, cytoband A2-B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:62026
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire coding region was replaced by a construct containing a beta-geo fusion gene, lacking a promoter. Recombination of the construct left the 5' flanking region intact, enabling the expression of the beta-geo transgene to be under the control of the endogenous promoter and regulatory sequences. (J:62026)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sox2 Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:62026
Zappone MV et al.,
"Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells."
Development 2000 Jun;127(11):2367-82
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All: |
3 reference(s)
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Analysis Tools
