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| Nomenclature |
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Symbol:
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Nr1h3tm1Djm
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Name:
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nuclear receptor subfamily 1, group H, member 3;
targeted mutation 1, David J Mangelsdorf
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MGI ID: |
MGI:2181380 |
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Synonyms: |
LXRalpha (-), Nr1h3- |
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Gene:
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Nr1h3
Location:
Chr2:91184061-91202834 bp, - strand
Genetic Position: Chr2,
50.52 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:47971
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 3-6 encoding the DNA-binding and ligand-binding domains (amino acids 87-327) were replaced with a neomycin resistance gene via homologous recombination. Northern blot and Western blot analysis of liver from homozygous mutant animals verified the absence of mRNA and protein expression. (J:47971)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:47971
Peet DJ et al.,
"Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha."
Cell 1998 May 29;93(5):693-704
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All: |
48 reference(s)
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Analysis Tools
