|
|
| Nomenclature |
|
Symbol:
|
Pdx1tm1Cvw
|
|
Name:
|
pancreatic and duodenal homeobox 1;
targeted mutation 1, Christopher V E Wright
|
|
MGI ID: |
MGI:2181360 |
|
Synonyms: |
Ipf1-, pdx-1 -, pdxXBko- |
|
Gene:
|
Pdx1
Location:
Chr5:147269959-147278008 bp, + strand
Genetic Position: Chr5,
86.84 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:32017
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Insertion of gene trap vector |
| |
|
Mutation details: The gene was disrupted by replacement of exon 2 with a neomycin resistance cassette resulting in the deletion of the DNA-binding homeodomain. Immunostaining of E9.5 embryos with antibodies directed against the N-terminus of the protein did not detect protein product. (J:32017)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:32017
Offield MF et al.,
"PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum."
Development 1996 Mar;122(3):983-95
|
|
All: |
14 reference(s)
|
|
Analysis Tools
