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| Nomenclature |
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Symbol:
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Bmpr1atm2.2Bhr
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Name:
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bone morphogenetic protein receptor, type 1A;
targeted mutation 2.2, Richard R Behringer
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MGI ID: |
MGI:2181295 |
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Synonyms: |
Bmpr1a-, deltae2, deltaexon2 |
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Gene:
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Bmpr1a
Location:
Chr14:34410734-34503341 bp, - strand
Genetic Position: Chr14,
20.81 cM
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Joint defects in Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr Tg(Gdf5-cre-ALPP)1Kng/0 mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75074
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Homologous recombination introduced a floxed neomycin resistance cassette into intron 2, and a single loxP site into intron 1. Cre-mediated recombination in vivo under the control of a CMV promoter excised the neo cassette and exon 2, which encodes roughly a third of the extracellular domain of the receptor within the ligand-binding domain. (J:75074)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Bmpr1a Mutation:
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65 strains or lines available |
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| References |
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Original: |
J:75074
Mishina Y et al.,
"Generation of Bmpr/Alk3 conditional knockout mice."
Genesis 2002 Feb;32(2):69-72
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All: |
12 reference(s)
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Analysis Tools
