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| Nomenclature |
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Symbol:
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Gpd2tm1Tka
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Name:
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glycerol phosphate dehydrogenase 2, mitochondrial;
targeted mutation 1, Takashi Kadowaki
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MGI ID: |
MGI:2181289 |
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Synonyms: |
mGPDH- |
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Gene:
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Gpd2
Location:
Chr2:57237635-57370719 bp, + strand
Genetic Position: Chr2,
31.66 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75839
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 5 via homologous recombination. The absence of protein expression was verified by Western blot and enzyme assay of islet samples from homozygous mutant animals. (J:75839)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gpd2 Mutation:
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51 strains or lines available |
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| References |
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Original: |
J:75839
Eto K et al.,
"Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion."
Science 1999 Feb 12;283(5404):981-5
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All: |
9 reference(s)
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Analysis Tools
