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| Nomenclature |
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Symbol:
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Csf2rbtm1Mur
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Name:
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colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage);
targeted mutation 1, Richard Murray
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MGI ID: |
MGI:2181261 |
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Synonyms: |
betac-, betac mutant |
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Gene:
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Csf2rb
Location:
Chr15:78325990-78351000 bp, + strand
Genetic Position: Chr15,
37.36 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:24122
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 4 was replaced by a neomycin cassette via homologous recombination. The deleted region encodes the third and fourth cysteine residues in the first repeat of the conserved motif of cytokine receptors. FACS analysis of bone marrow cells isolated from homozygous mutant mice showed a lack of a functional receptor. Additional FACS analysis showed that expression of the homologous protein, Csf3rb2, was intact. (J:24122)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Csf2rb Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:24122
Nishinakamura R et al.,
"Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal."
Immunity 1995 Mar;2(3):211-22
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All: |
6 reference(s)
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Analysis Tools
