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| Nomenclature |
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Symbol:
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Serpinf2tm1Hrl
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Name:
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serine (or cysteine) peptidase inhibitor, clade F, member 2;
targeted mutation 1, H Roger Lijnen
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MGI ID: |
MGI:2181226 |
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Synonyms: |
alpha-2-AP-, alpha2-AP- |
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Gene:
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Serpinf2
Location:
Chr11:75431732-75439591 bp, - strand
Genetic Position: Chr11,
45.89 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:54047
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced the entire coding region (exon 2 through the stop codon in exon 10). RT-PCR analaysis of kidney and liver tissue showed an absence of transcript in homozygous mutant mice. Western blot analyses of unactivated and activated plasma confirmed a lack of encoded protein in homozygous mice. Complex formation was undetectable by blotting analysis of plasma incubated with purified plasmin. (J:43244, J:54047)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Serpinf2 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:54047
Lijnen HR et al.,
"Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding."
Blood 1999 Apr 1;93(7):2274-81
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All: |
12 reference(s)
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Analysis Tools
