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| Nomenclature |
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Symbol:
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Cry2tm1Asn
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Name:
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cryptochrome 2 (photolyase-like);
targeted mutation 1, Aziz Sancar
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MGI ID: |
MGI:2181212 |
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Synonyms: |
Cry2-, mCry2- |
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Gene:
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Cry2
Location:
Chr2:92403646-92434043 bp, - strand
Genetic Position: Chr2,
51.01 cM, cytoband E
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Retinal degeneration in Pde6brd1/Pde6brd1, and Pde6brd1/Pde6brd1 Cry1tm1Asn/Cry1tm1Asn Cry2tm1Asn/Cry2tm1Asn mouse retinas
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:51110
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a 1.1-kb region encoding the FAD-binding domain. Northern blot analysis and in situ hybridization showed a lack of transcript and protein in homozygous mutant mice. (J:51110)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:51110
Thresher RJ et al.,
"Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses."
Science 1998 Nov 20;282(5393):1490-4
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All: |
29 reference(s)
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Analysis Tools
