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| Nomenclature |
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Symbol:
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Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
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Name:
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transgene insertion 1, Christophe Benoist
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MGI ID: |
MGI:2181203 |
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Synonyms: |
BDC-2.5/N TCR Tg, Tg(TcraBDC2.5)2Doi, Tg(TcrbBDC2.5)2Doi |
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Transgene:
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Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene results from the coinjection of two constructs derived from diabetogenic T-cell clone BDC2.5. The Tcra construct contains a rearranged Tcra sequence (V alpha J alpha) that begins 20 bp 5' of the ATG site and ends 30 bp 3' of the splice donor sequence of J alpha 17. The 6.5 Tcrb construct contains rearranged Tcrb sequence (V beta D beta J beta) flanked by 2 kb of 5' regulatory sequences and 3.5 kb of 3' DNA containing the unrearranged J beta 1.3 to J beta 1.6 sequences, and precedes a 12 kb sequence containing the C beta 2 region. (J:77007)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:77007
Katz JD et al.,
"Following a diabetogenic T cell from genesis through pathogenesis."
Cell 1993 Sep 24;74(6):1089-100
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All: |
79 reference(s)
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Analysis Tools
