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| Nomenclature |
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Symbol:
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Crxtm1Clc
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Name:
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cone-rod homeobox containing gene;
targeted mutation 1, Constance L Cepko
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MGI ID: |
MGI:2181191 |
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Synonyms: |
Crx- |
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Gene:
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Crx
Location:
Chr7:15865947-15879968 bp, - strand
Genetic Position: Chr7,
8.6 cM
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Outer retina microscopy of Crxtm1Clc/Crxtm1Clc mice
Show the 7 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58796
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The homeodomain coding region containing exon 3 and a portion of exon 4 was replaced by a neomycin selection cassette. RT-PCR analysis showed an absence of transcript in the retinas of homozygous mutant mice. (J:58796)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:58796
Furukawa T et al.,
"Retinopathy and attenuated circadian entrainment in Crx-deficient mice."
Nat Genet 1999 Dec;23(4):466-70
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All: |
14 reference(s)
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Analysis Tools
