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| Nomenclature |
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Symbol:
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Bmp4tm3.1Blh
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Name:
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bone morphogenetic protein 4;
targeted mutation 3.1, Brigid L Hogan
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MGI ID: |
MGI:2181190 |
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Synonyms: |
BMP4-fx, Bmp4loxP-lacZ |
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Gene:
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Bmp4
Location:
Chr14:46383520-46390669 bp, - strand
Genetic Position: Chr14,
23.95 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75136
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: This hypomorphic allele is a derivative of Bmp4tm3Blh. LoxP sites were inserted flanking exons 3 and 4, and a promoterless lacZ gene was inserted 3' to the loxP insertions. An frt-flanked neomycin selection cassette that was inserted downstream of of the lacZ gene was removed by Flpe mediated recombination in the final allele. (J:75136)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Bmp4 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:75136
Kulessa H et al.,
"Generation of a loxP flanked bmp4(loxP-lacZ) allele marked by conditional lacZ expression."
Genesis 2002 Feb;32(2):66-8
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All: |
12 reference(s)
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Analysis Tools
