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| Nomenclature |
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Symbol:
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Krt10tm1Tmm
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Name:
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keratin 10;
targeted mutation 1, Thomas M Magin
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MGI ID: |
MGI:2180882 |
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Gene:
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Krt10
Location:
Chr11:99385254-99389364 bp, - strand
Genetic Position: Chr11,
62.92 cM
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Krt10tm1Tmm/Krt10tm1Tmm mice show large areas of skin loss while Krt10tm1Tmm/Krt10+ mice show hyperkeratotic scaling of the skin
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:31853
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 3 through 7 were replaced by an HPRT cassette. Northern analysis showed a lack of transcript in homozygous mutant mice. (J:31853)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:31853
Porter RM et al.,
"Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis."
J Cell Biol 1996 Mar;132(5):925-36
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All: |
6 reference(s)
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Analysis Tools
