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| Nomenclature |
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Symbol:
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Sim2tm1Fan
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Name:
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single-minded homolog 2 (Drosophila);
targeted mutation 1, Chen-Ming Fan
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MGI ID: |
MGI:2180881 |
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Gene:
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Sim2
Location:
Chr16:94085260-94127032 bp, + strand
Genetic Position: Chr16,
55.05 cM, cytoband C3.3-C4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76787
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 422 bp of the 5' untranslated region and the first 144 bp of the gene coding region were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the first 48 amino acids of the basic helix-loop-helix domain. Gene expression is absent in kidneys from homozygous mutant animals as determined by in situ hybridization. (J:76787)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sim2 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:76787
Goshu E et al.,
"Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants."
Mol Cell Biol 2002 Jun;22(12):4147-57
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All: |
5 reference(s)
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Analysis Tools
